Service
We bring together advanced platforms across mRNA, viral vectors, cell and gene therapies, and biologics to drive the development and manufacturing of next-generation therapeutics.
Service
We bring together advanced platforms across mRNA, viral vectors, cell and gene therapies, and biologics to drive the development and manufacturing of next-generation therapeutics.
Digital Manufacturing Platform
Data
Center
Inline data collection
Data analysis & integration
Intelligent
Center
Deep Learning
Modeling & simulation
Control
Center
Model predictive control
Real-time
Monitoring System
Automatic
Feedback Control
Real-time
Monitoring System
- Linking manufacturing
equipment and monitoring instruments
Seamlessly integrating upstream and downstream devices, as well as various types of analytical instruments.
- Real-time data transmission to the data center
Different equipment transmitting data to the processing center via OPC.
Data Collection
and Processing
- Automated equipment analysis and online process data analysis
The data center analyzes and manages uploaded data at any time, providing real-time insights.
Cloud
Storage
- Paperless operation throughout the entire facility
Cloud-based digital transmission of important parameters, achieving a paperless manufacturing process.
- Cloud network connecting various plants
- manufacturing parameter data transmitted between networks, allowing smooth data flow between different plants and simultaneously collecting data from various production lines.
Nucleic Acid
TBMC provide one-shop Nucleic Acid production service from research to clinical stage with advanced one-step synthesis technology
Target DNA
mRNA
mRNA-LNP
Drug Product
Service for research and pre-clinical stage: provide high quality plasmid DNA production, mRNA sequence
optimization, mRNA IVT, and
mRNA-LNP packaging services
optimization, mRNA IVT, and
mRNA-LNP packaging services
Scaleㅤ1mL～5L（mg to 10 g）
Service for clinical or marketing stage： high quality plasmid DNA production, mRNA sequence
optimization, mRNA IVT, mRNA-LNP packaging, and DP fill-in
Scaleㅤ63 batch per year, 13 million dose vaccine per year
Gene Therapy
TBMC provides end-to-end one shop service for lentiviral vector or adeno associate viral vector production
LVV
Target DNA
Transfection
LVV
Drug Product
AAV
Target DNA
Transfection
AAV
Drug Product
Service for research and pre-clinical stage：provide viral suspension cell culture process development、viral vector production and purification
Scaleㅤ250mL～5L
Yield AAV E14 vg/L
LVV E7 Tu/mLService for clinical or marketing stage：viral vector production、
purificaition and PD fill-in
Cell Therapy
TBMC is developing an automated platform for the mass production of MSC, CAR-T and other immunotherapy cell therapy drugs. We also offer comprehensive one-stop services including IRB planning and writing, process development, QC method
establishment, functional verification, CMC (Chemistry, Manufacturing, and
Controls) document preparation, as well as clinical trial design.
Tissue/Cell source
．Tissue collection IRB
．Pathogen detection
．Cell separation and purification
．Cell cryopreservation
．Pathogen detection
．Cell separation and purification
．Cell cryopreservation
Cell manufacturing
．Cell culture scale-up, process development
．QC method development
．Cell product spec
．In vitro assay
．QC method development
．Cell product spec
．In vitro assay
Safety and Efficacy Test
．In vivo assay
．Toxicity Study
．Dosage test
．Stability test
．Toxicity Study
．Dosage test
．Stability test
Clinical Trial IND
．CMC document
．Clinical trial protocol
．IND document
．Clinical trial
．Clinical trial protocol
．IND document
．Clinical trial
Market NDA
．Clinical trial data analysis
．BLA application
．Production manufacturing and process optimization
．BLA application
．Production manufacturing and process optimization
CHO-C Protein Drug Platform
TBMC develops proprietary CHO-C platform aiming to provide end-to-end protein production services from research to marketing stage
10,000
100
10
10,000
Number of sequences